|2016-12-17 ||Evolution of HIV virulence in response to widespread scale up of antiretroviral therapy: a modeling study|
Herbeck JT, Mittler JE, Gottlieb GS, Goodreau SM, Murphy JT, Cori A, Pickles M, Fraser C
Recommended by Samuel Alizon and Roger Kouyos
Predicting HIV virulence evolution in response to widespread treatment
It is a classical result in the virulence evolution literature that treatments decreasing parasite replication within the host should select for higher replication rates, thus driving increased levels of virulence if the two are correlated. There is some evidence for this in vitro but very little in the field. HIV infections in humans offer a unique opportunity to go beyond the simple predictions that treatments should favour more virulent strains because many details of this host-parasite syste...