BEDHOMME Stephanie

  • Centre d'Ecologie Fonctionnelle et Evolutive, CNRS, Montpellier, France
  • Adaptation, Experimental Evolution, Genome Evolution, Genotype-Phenotype, Life History
  • recommender

2014- : CR1 CNRS, CEFE 2012-13: Postdoc at Bellvitge Biomedical Research Institute (IDIBELL, Barcelona, Spain) 2009-12: Postdoc at the Molecular and Cellular Plant Biology Institute (IBMCP, Valencia, Spain) 2007-09: Teaching and research assistant, Münster University (Germany) 2005-07: Postdoc at Queen’s University (Kingston, Canada) 2000-04: PhD in the Genetic and Evolution of Infectious Disease laboratory (IRD, Montpellier)

Selected publications: Mengual-Chuliá B., Bedhomme, S., Lafforgue, G., Elena, S.F., Bravo, I.G. (2016) Assessing parallel gene histories in viral genomes. BMC Evolutionary Biology 16:32. Bedhomme S., Hillung, J. and Elena S.F. (2015). Emerging viruses: why they are not jacks of all trades? Current Opinion in Virology 10:1–6. Bedhomme, S.,Lafforgue, G. and Elena S.F. (2012) Multihost experimental evolution of a plant RNA virus reveals local adaptation and host specific mutations. Molecular Biology and Evolution 29:1481–1492. Amoros-Moya, D., Bedhomme, S., Hermann, M. and Bravo, I.G. (2010) Evolution in regulatory regions rapidly compensates the cost of non-optimal codon usage. Molecular Biology and Evolution 27: 2141–2151. Prasad, N.G., Bedhomme, S., Day, T. and Chippindale, A.K. (2007) An evolutionary cost of separate genders revealed by male-limited evolution. American Naturalist 169: 29–37. Bedhomme, S., Agnew, P., Sidobre, C., Vital P.O. Y. and Michalakis, Y. (2005) Prevalence-dependent costs of parasite virulence. PLoS Biology 3: e262. Bedhomme, S., Agnew, P., Sidobre, C. and Michalakis, Y. (2004) Virulence reaction norms across a food gradient. Proceedings of the Royal Society of London B 271: 739-744.

3 recommendations

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Identifying drivers of parallel evolution: A regression model approach
Susan F Bailey, Qianyun Guo, Thomas Bataillon

Recommended by Stephanie Bedhomme based on reviews by Bastien Boussau and 1 anonymous reviewer
A new statistical tool to identify the determinant of parallel evolution

In experimental evolution followed by whole genome resequencing, parallel evolution, defined as the increase in frequency of identical changes in independent populations adapting to the same environment, is often considered as the product of similar selection pressures and the parallel changes are interpreted as adaptive.
However, theory predicts that heterogeneity both in mutation rate and selection intensity across the genome can trigger patterns of parallel evolution. It is thus important...

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Things softly attained are long retained: Dissecting the Impacts of Selection Regimes on Polymorphism Maintenance in Experimental Spatially Heterogeneous Environments
Romain Gallet, Rémy Froissart, Virginie Ravigné

Recommended by Stephanie Bedhomme based on reviews by Joachim Hermisson and 2 anonymous reviewers
Experimental test of the conditions of maintenance of polymorphism under hard and soft selection


Theoretical work, initiated by Levene (1953) [1] and Dempster (1955) [2], suggests that within a given environment, the way populations are regulated and contribute to the next generation is a key factor for the maintenance of local adaptation polymorphism. In this theoretical context, hard selection describes the situation where the genetic composition of each population affects its contribution to the next generation whereas soft selection describes the case where the contribution of...

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Experimental Evolution of Gene Expression and Plasticity in Alternative Selective Regimes
Huang Y, Agrawal AF

Recommended by Luis-Miguel Chevin and Stephanie Bedhomme
Genetic adaptation counters phenotypic plasticity in experimental evolution

How do phenotypic plasticity and adaptive evolution interact in a novel or changing environment? Does evolution by natural selection generally reinforce initially plastic phenotypic responses, or does it instead oppose them? And to what extent does evolution of a trait involve evolution of its plasticity? These questions have lied at the heart of research on phenotypic evolution in heterogeneous environments ever since it was realized that the environment is likely to affect the expression of m...


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