|2016-12-14 ||The Red Queen lives: epistasis between linked resistance loci|
Metzger CMJA, Luijckx P, Bento G, Mariadassou M, Ebert D.
Recommended by Adele Mennerat and Thierry Lefèvre
Evidence of epistasis provides further support to the Red Queen theory of host-parasite coevolution
According to the Red Queen theory of antagonistic host-parasite coevolution, adaptation of parasites to the most common host genotype results in negative frequency-dependent selection whereby rare host genotypes are favoured. Assuming that host resistance relies on a genetic host-parasite (mis)match involving several linked loci, then recombination appears as much more efficient than parthenogenesis in generating new resistant host genotypes. This has long been proposed to explain one of the big...