ACHAZ Guillaume

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  • ISYEB and CIRB, MNHN / Univ. Pierre et Marie Curie / Collège de France, Paris, France
  • Adaptation, Bioinformatics & Computational Biology, Evolutionary Applications, Evolutionary Theory, Genome Evolution, Macroevolution, Molecular Evolution, Other, Phylogenetics / Phylogenomics, Population Genetics / Genomics
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2018-11-21
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PREPRINT
Convergent evolution as an indicator for selection during acute HIV-1 infection
Frederic Bertels, Karin J Metzner, Roland R Regoes
https://doi.org/10.1101/168260

Recommended by Guillaume Achaz based on reviews by Jeffrey Townsend and 2 anonymous reviewers
Is convergence an evidence for positive selection?

The preprint by Bertels et al. [1] reports an interesting application of the well-accepted idea that positively selected traits (here variants) can appear several times independently; think about the textbook examples of flight capacity. Hence, the authors assume that reciprocally convergence implies positive selection. The methodology becomes then, in principle, straightforward as one can simply count variants in independent datasets to detect convergent mutations.
In this preprint, the ...

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