|Separate the wheat from the chaff: genomic analysis of local adaptation in the red coral Corallium rubrum|
Pratlong M, Haguenauer A, Brener K, Mitta G, Toulza E, Garrabou J, Bensoussan N, Pontarotti P, Aurelle D
Recommended by Guillaume Achaz based on reviews by Lucas Gonçalves da Silva and 1 anonymous reviewer
Pros and Cons of local adaptation scans
The preprint by Pratlong et al.  is a well thought quest for genomic regions involved in local adaptation to depth in a species a red coral living the Mediterranean Sea. It first describes a pattern of structuration and then attempts to find candidate genes involved in local adaptation by contrasting deep with shallow populations. Although the pattern of structuration is clear and meaningful, the candidate genomic regions involved in local adaptation remain to be confirmed. Two external revie...
|Convergent evolution as an indicator for selection during acute HIV-1 infection|
Frederic Bertels, Karin J Metzner, Roland R Regoes
Recommended by Guillaume Achaz based on reviews by Jeffrey Townsend and 2 anonymous reviewers
Is convergence an evidence for positive selection?
The preprint by Bertels et al.  reports an interesting application of the well-accepted idea that positively selected traits (here variants) can appear several times independently; think about the textbook examples of flight capacity. Hence, the authors assume that reciprocally convergence implies positive selection. The methodology becomes then, in principle, straightforward as one can simply count variants in independent datasets to detect convergent mutations.
In this preprint, the ...