|Convergent evolution as an indicator for selection during acute HIV-1 infection|
Frederic Bertels, Karin J Metzner, Roland R Regoes
Recommended by Guillaume Achaz based on reviews by Jeffrey Townsend and 2 anonymous reviewers
Is convergence an evidence for positive selection?
The preprint by Bertels et al.  reports an interesting application of the well-accepted idea that positively selected traits (here variants) can appear several times independently; think about the textbook examples of flight capacity. Hence, the authors assume that reciprocally convergence implies positive selection. The methodology becomes then, in principle, straightforward as one can simply count variants in independent datasets to detect convergent mutations.
In this preprint, the ...