|2017-11-20 ||Effects of partial selfing on the equilibrium genetic variance, mutation load and inbreeding depression under stabilizing selection|
Diala Abu Awad and Denis Roze
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Understanding genetic variance, load, and inbreeding depression with selfing
A classic problem in evolutionary biology is to understand the genetic variance in fitness. The simplest hypothesis is that variation exists, even in well-adapted populations, as a result of the balance between mutational input and selective elimination. This variation causes a reduction in mean fitness, known as the mutation load. Though mutation load is difficult to quantify empirically, indirect evidence of segregating genetic variation in fitness is often readily obtained by comparing the f...