GANDON Sylvain

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  • CEFE, CNRS, Montpellier, France
  • Evolutionary Ecology, Evolutionary Epidemiology, Evolutionary Theory, Experimental Evolution, Life History, Other, Phenotypic Plasticity
  • recommender

2 recommendations

2020-02-17
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Epistasis, inbreeding depression and the evolution of self-fertilization
Diala Abu Awad and Denis Roze
10.1101/809814

Recommended by Sylvain Gandon based on reviews by Nick Barton and 1 anonymous reviewer
Epistasis and the evolution of selfing

The evolution of selfing results from a balance between multiple evolutionary forces. Selfing provides an "automatic advantage" due to the higher efficiency of selfers to transmit their genes via selfed and outcrossed offspring. Selfed offspring, however, may suffer from inbreeding depression. In principle the ultimate evolutionary outcome is easy to predict from the relative magnitude of these two evolutionary forces [1,2]. Yet, several studies explicitly taking into account the genetic archite...

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2017-03-31
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Human adaptation of Ebola virus during the West African outbreak
Urbanowicz, R.A., McClure, C.P., Sakuntabhai, A., Sall, A.A., Kobinger, G., M├╝ller, M.A., Holmes, E.C., Rey, F.A., Simon-Loriere, E., and Ball, J.K.
10.1016/j.cell.2016.10.013

Recommended by Sylvain Gandon and S├ębastien Lion
Ebola evolution during the 2013-2016 outbreak

The Ebola virus (EBOV) epidemic that started in December 2013 resulted in around 28,000 cases and more than 11,000 deaths. Since the emergence of the disease in Zaire in 1976 the virus had produced a number of outbreaks in Africa but until 2013 the reported numbers of human cases had never risen above 500. Could this exceptional epidemic size be due to the spread of a human-adapted form of the virus?

The large mutation rate of the virus [1-2] may indeed introduce massive amounts of genetic va...

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