|2019-02-05 ||The quiescent X, the replicative Y and the Autosomes|
Guillaume Achaz, Serge Gangloff, Benoit Arcangioli
Recommended by Nicolas Galtier based on reviews by Robert Lanfear and Marc Robinson-Rechavi
Replication-independent mutations: a universal signature ?
Mutations are the primary source of genetic variation, and there is an obvious interest in characterizing and understanding the processes by which they appear. One particularly important question is the relative abundance, and nature, of replication-dependent and replication-independent mutations - the former arise as cells replicate due to DNA polymerization errors, whereas the latter are unrelated to the cell cycle. A recent experimental study in fission yeast identified a signature of mutatio...
|2017-11-10 ||Rates of Molecular Evolution Suggest Natural History of Life History Traits and a Post-K-Pg Nocturnal Bottleneck of Placentals|
Wu J, Yonezawa T, Kishino H.
Recommended by Nicolas Galtier and Belinda Chang
A new approach to DNA-aided ancestral trait reconstruction in mammals
Reconstructing ancestral character states is an exciting but difficult problem. The fossil record carries a great deal of information, but it is incomplete and not always easy to connect to data from modern species. Alternatively, ancestral states can be estimated by modelling trait evolution across a phylogeny, and fitting to values observed in extant species. This approach, however, is heavily dependent on the underlying assumptions, and typically results in wide confidence intervals.