|2019-11-26 ||Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multi-trait GWA studies|
Jobran Chebib and Frédéric Guillaume
Recommended by Kathleen Lotterhos based on reviews by Pär Ingvarsson and 1 anonymous reviewer
Understanding the effects of linkage and pleiotropy on evolutionary adaptation
Genetic correlations among traits are ubiquitous in nature. However, we still have a limited understanding of the genetic architecture of trait correlations. Some genetic correlations among traits arise because of pleiotropy - single mutations or genotypes that have effects on multiple traits. Other genetic correlations among traits arise because of linkage among mutations that have independent effects on different traits. Teasing apart the differential effects of pleiotropy and linkage on trait...