BRAVO Ignacio

  • Laboratory MIVEGEC UMR CNRS IRD UniMontp, Centre National de la Recherche Scientifique (CNRS), Montpellier, France
  • Evolutionary Applications, Evolutionary Epidemiology, Experimental Evolution, Genome Evolution, Molecular Evolution, Other, Phylogenetics / Phylogenomics, Systematics / Taxonomy
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Academic Career 2015->> Research Director. French National Center for Scientific Research (CNRS), Montpellier, France. 2011-2015 Head of the Infections and Cancer Laboratory. Catalan Institute of Oncology (ICO), Barcelona, Spain. 2008-2011 Ram√≥n y Cajal Research Fellow. Centre for Public Health Research (CSISP). Valencia. Spain. 2007-2008 Junior Professorship. Institute for Evolution and Biodiversity. University M√ľnster, M√ľnster, Germany. 2006. EMBO Short term fellowship (3 months). Laboratory Prof. Dr. Herv√© Philippe. Universit√© de Montr√©al, Canada. 2006-2007 Research Scientist. Laboratory Prof. Dr. Lutz Gissmann, Genome Modifications and Carcinogenesis, German Cancer Research Centre, Heidelberg, Germany. 2002-2006 Postdoctoral researcher. Laboratory Prof. Dr. AŐĀngel Alonso Cell Differentiation, German Cancer Research Centre, Heidelberg, Germany. 1998-2002 PhD in Biology. 2002. Universidad de Le√≥n, Spain.

Selected recent publications Pimenoff V, Mendes de Oliveira C, Bravo IG. Transmission between Archaic and Modern Human Ancestors during the Evolution of the Oncogenic Human Papillomavirus 16. Mol Biol Evol. 2017 Jan;34(1):4-19. doi: 10.1093/molbev/msw214. Nicol√°s-P√°rraga S, Gandini C, Pimenoff VN, Alemany L, de Sanjos√© S, Bosch FX and Bravo IG*. HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus. Cancer Med. 2016 Oct;5(10):2909-2919. doi: 10.1002/cam4.870. Mengual-Chuli√° B, Bedhomme S, Lafforgue G, Elena SF, Bravo IG. Assessing parallel gene histories in viral genomes. BMC Evol Biol. 2016 Feb 5;16(1):32. doi: 10.1186/s12862-016-0605-4. F√©lez-S√°nchez M, Tr√∂semeier JH, Bedhomme S, Gonz√°lez-Bravo MI, Kamp C, Bravo IG. Cancer, Warts, or Asymptomatic Infections: Clinical Presentation Matches Codon Usage Preferences in Human Papillomaviruses. Genome Biol Evol. 2015 Jul 1;7(8):2117-35. doi: 10.1093/gbe/evv129. Bravo IG and F√©lez-S√°nchez M. ‚ÄúPapillomaviruses: viral evolution, cancer and evolutionary medicine". Evol Med Public Health. 2015 Jan 28;2015(1):32-51. doi: 10.1093/emph/eov003. Garcia-Perez, R, Ibanez C, Godinez JM, Arechiga N, Garin I, Perez-Suarez G, de Paz O, Juste J, Echevarria JE, Bravo IG.‚Ä® ‚ÄúNovel papillomaviruses in free-ranging Iberian bats: no virus-host co-evolution, no strict host specificity and hints for recombination‚ÄĚ. ‚Ä®Genome Biol Evol (2014) 6(1):94-104. doi: 10.1093/gbe/evt211 God√≠nez JM, Nicol√°s-P√°rraga S, Pimenoff VN, Mengual-Chuli√° B, Mu√Īoz N, Bosch FX, S√°nchez GI, McCloskey J, Bravo IG. ‚ÄúPhylogenetically related, clinically different: human papillomaviruses 6 and 11 variants distribution in genital warts and in laryngeal papillomatosis‚ÄĚ. Clin Microbiol Infect. (2014) 20(6):O406-13. doi: 10.1111/1469-0691.12420.

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Negative frequency-dependent selection is frequently confounding
Dustin Brisson

Recommended by Ignacio Bravo based on reviews by David Baltrus and 2 anonymous reviewers
Unmasking the delusive appearance of negative frequency-dependent selection

Explaining the processes that maintain polymorphisms in a population has been a fundamental line of research in evolutionary biology. One of the main mechanisms identified that preserves genetic diversity is negative frequency-dependent selection (NFDS), which constitutes a powerful framework for interpreting the presence of persistent polymorphisms. Nevertheless, a number of patterns that are often explained by invoking NFDS may also be compatible with, and possibly more easily explained by, di...


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