FABRE Frédéric

  • SAVE Santé et Agroécologie du Vignoble (UMR 1065), INRA, Bordeaux, France
  • Bioinformatics & Computational Biology, Evolutionary Applications, Evolutionary Epidemiology, Evolutionary Theory, Experimental Evolution
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I completed a training as agronomist at Agrocampus Rennes (1996-1999). After a first working experience at CIRAD (Saint Pierre de la Reunion) in applied entomology (2000-2001), I obtained a PhD in Applied Ecology and Agronomy (2001-2004). I developped a decision support system to improve the management of a viral disease of cereals. Since 2006 I'm a researcher at INRA. My scientific interests are related with the epidemiology and evolutionary biology of plant pathogens. My work aim to understand the interplay between the evolutionary and epidemiological processes acting on plant virus and plant fungi population from the host to the landscape scales. To this end, I mainly use mathematical models and statistical methods. An applied perspective is to derive durable management strategies of plant disease resistance in agricultural ecosystems. I'm also interest in decision support system bridging the gap between scientific knowledge and end-users making day-to-day crop management decisions.

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2017-04-12
Genetic drift, purifying selection and vector genotype shape dengue virus intra-host genetic diversity in mosquitoes
Lequime S, Fontaine A, Gouilh MA, Moltini-Conclois I and Lambrechts L
http://dx.doi.org/10.1371/journal.pgen.1006111

Recommended by Frédéric Fabre and Benoit Moury
Vectors as motors (of virus evolution)

Many viruses are transmitted by biological vectors, i.e. organisms that transfer the virus from one host to another. Dengue virus (DENV) is one of them. Dengue is a mosquito-borne viral disease that has rapidly spread around the world since the 1940s. One recent estimate indicates 390 million dengue infections per year [1]. As many arthropod-borne vertebrate viruses, DENV has to cross several anatomical barriers in the vector, to multiply in its body and to invade its salivary glands before gett...

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