FRAGATA InĂŞs

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  • MITE2: Multidisciplinary Investigation Targeting Ecology and Evolution, cE3c/FCUL, Lisbon, Portugal
  • Adaptation, Evolutionary Dynamics, Evolutionary Ecology, Experimental Evolution, Genotype-Phenotype, Life History, Molecular Evolution, Phenotypic Plasticity, Population Genetics / Genomics, Species interactions
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I am broadly interested the ecological and evolutionary mechanisms involved in the maintenance of phenotypic and genetic diversity and also on how selection, drift, mutation and species interactions shape biodiversity within an ecosystem. Currently I am Postdoc in the “Adaptation in heterogeneous environments“ team. My research focus on investigating 1) how metal accumulation and previous evolutionary history affect herbivore coexistence, and 2) what is the impact of high metal adaptation and coevolution on survivability in different environments To answer these questions I use spider mites and tomato plants in combination with experimental evolution and modelling.

I developed my PhD thesis with Margarida Matos (cE3c, FCUL) and Mauro Santos (Universitat Autònoma de Barcelona) on “The role of history, chance and selection during adaptation: an integrated perspective.” During my thesis I followed the real-time evolutionary trajectory of Drosophila subobscura populations from contrasting locations, during their adaptation to a common environment.

After my PhD, I was a postdoc in Claudia Bank’s lab in the Instituto Gulbenkian de Ciência (IGC) for three years and a half, focusing on statistical and mathematical modelling and data analyses. Namely, I investigated 1) the effects of synonymous mutations on adaptive path accessibility; 2) the distribution of fitness effects of new mutations under different environmental conditions and gene expression levels (in collaboration with Dan Bolon, UMass); and 3) the predictability and repeatability of evolution during adaptation to the laboratory environment (in collaboration with the "Local adaptation in Drosophila" team).

2 recommendations

2018-06-03
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Cost of resistance: an unreasonably expensive concept
Thomas Lenormand, Noemie Harmand, Romain Gallet
10.1101/276675

Recommended by InĂŞs Fragata and Claudia Bank based on reviews by Helen Alexander, Danna Gifford and 1 anonymous reviewer
Let’s move beyond costs of resistance!

The increase in the prevalence of (antibiotic) resistance has become a major global health concern and is an excellent example of the impact of real-time evolution on human society. This has led to a boom of studies that investigate the mechanisms and factors involved in the evolution of resistance, and to the spread of the concept of "costs of resistance". This concept refers to the relative fitness disadvantage of a drug-resistant genotype compared to a non-resistant reference genotype in the ...

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2017-08-03
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Fisher's geometrical model and the mutational patterns of antibiotic resistance across dose gradients
Noémie Harmand, Romain Gallet, Roula Jabbour-Zahab, Guillaume Martin, Thomas Lenormand
10.1111/evo.13111

Recommended by InĂŞs Fragata and Claudia Bank
What doesn’t kill us makes us stronger: can Fisher’s Geometric model predict antibiotic resistance evolution?

The increasing number of reported cases of antibiotic resistance is one of today’s major public health concerns. Dealing with this threat involves understanding what drives the evolution of antibiotic resistance and investigating whether we can predict (and subsequently avoid or circumvent) it [1].
One of the most illustrative and common models of adaptation (and, hence, resistance evolution) is Fisher’s Geometric Model (FGM). The original model maps phenotypes to fitness, meaning that ea...

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