KISHINO Hirohisa

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  • Laboratory of Biometry and Bioinformatics, The University of Tokyo, Tokyo, Japan
  • Genome Evolution, Molecular Evolution, Morphological Evolution, Phylogenetics / Phylogenomics, Phylogeography & Biogeography, Population Genetics / Genomics
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I studied stochastic processes at graduate course, and joined the Institute of Statistical Mathematics. Masami Hasegawa introduced me to the field of molecular phylogenetics in mid 1980s. Now I am attracted by evolutionary study in general, and interested in bridging molecular evolution and phenotype/functional evolution in particular.

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2019-02-08
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Genome plasticity in Papillomaviruses and de novo emergence of E5 oncogenes
Anouk Willemsen, Marta Félez-Sánchez, and Ignacio G. Bravo
10.1101/337477

Recommended by Hirohisa Kishino based on reviews by Leonardo de Oliveira Martins and 1 anonymous reviewer
E5, the third oncogene of Papillomavirus

Papillomaviruses (PVs) infect almost all mammals and possibly amniotes and bony fishes. While most of them have no significant effects on the hosts, some induce physical lesions. Phylogeny of PVs consists of a few crown groups [1], among which AlphaPVs that infect primates including human have been well studied. They are associated to largely different clinical manifestations: non-oncogenic PVs causing anogenital warts, oncogenic and non-oncogenic PVs causing mucosal lesions, and non-oncogenic P...

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