146

Title

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparumuse asterix (*) to get italics

Authors

Amelie Vantaux, Franck Yao, Domonbabele FdS Hien, Edwige Guissou, Bienvenue K Yameogo, Louis-Clement Gouagna, Didier Fontenille, Francois Renaud, Frederic Simard, Carlo Constantini, Frederic Thomas, Karine Mouline, Benjamin Roche, Anna Cohuet, Kounbobr R Dabire, Thierry LefevrePlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year

2018

Picture

Abstract

<p>Whether the malaria parasite *Plasmodium falciparum* can manipulate mosquito host choice in ways that enhance parasite transmission toward human is unknown. We assessed the influence of *P. falciparum* on the blood-feeding behaviour of three of its major vectors (*Anopheles coluzzii*, *An. gambiae* and *An. arabiensis*) in Burkina Faso. Host preferences assays using odor-baited traps revealed no effect of infection on mosquito long-range anthropophily. However, the identification of the blood meal origin of mosquitoes showed that females carrying sporozoites, the mature transmissible stage of the parasite, displayed a 24% increase in anthropophagy compared to both females harbouring oocysts, the parasite immature stage, and uninfected individuals. Using a mathematical model, we further showed that this increased anthropophagy in infectious females resulted in a > 250% increase in parasite transmission potential, everything else being equal. This important epidemiological consequence highlights the importance of vector control tools targeting infectious females.</p>

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https://doi.org/10.5281/zenodo.1296744You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

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Keywords

Anopheles, malaria, host manipulation by parasites, host preference, host selection

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields

Evolutionary Ecology

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Submission date

2018-02-28 09:12:14

Recommender

Alison Duncan

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