149

Title *

Cost of resistance: an unreasonably expensive conceptuse asterix (*) to get italics

Authors *

Thomas Lenormand, Noemie Harmand, Romain GalletPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2018

Picture *

Abstract *

<p>The cost of resistance, or the fitness effect of resistance mutation in absence of the drug, is a very widepsread concept in evolutionary genetics and beyond. It has represented an important addition to the simplistic view that resistance mutations should solely be considered as beneficial mutations. Yet, this concept also entails a series of serious difficulties in its definition, interpretation and current usage. In many cases, it may be simpler, clearer, and more insightful to study, measure and analyze the fitness effects of mutations across environments and to better distinguish those effects from "pleiotropic effects" of those mutations.</p>

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You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@evolbiol.peercommunityin.org). In case all raw scripts are included in the preprint, indicate the DOI or URL of the preprint. *

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Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@evolbiol.peercommunityin.org). In case all raw codes are included in the preprint, indicate the DOI or URL of the preprint. *

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Keywords (optional)

pleiotropy, trade-offs, adaptation, resistance, compensatory evolution, fitness landscape

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Adaptation, Evolutionary Applications, Evolutionary Ecology, Evolutionary Theory, Experimental Evolution, Genotype-Phenotype, Population Genetics / Genomics

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Submission date

2018-03-09 02:22:07

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