252

Title *

The Y chromosome may contribute to sex-specific ageing in Drosophila use asterix (*) to get italics

Authors *

Emily J Brown, Alison H Nguyen, Doris Bachtrog Please use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2020

Picture *

Abstract *

<p>Heterochromatin suppresses repetitive DNA, and a loss of heterochromatin has been observed in aged cells of several species, including humans and *Drosophila*. Males often contain substantially more heterochromatic DNA than females, due to the presence of a large, repeat-rich Y chromosome, and male flies generally have a shorter average lifespan than females. Here we show that repetitive DNA becomes de-repressed more rapidly in old male flies relative to females, and repeats on the Y chromosome are disproportionally mis-expressed during ageing. This is associated with a loss of heterochromatin at repetitive elements during ageing in male flies, and a general loss of repressive chromatin in aged males away from pericentromeric regions and the Y. By generating flies with different sex chromosome karyotypes (XXY females and X0 and XYY males), we show that repeat de-repression and average lifespan is correlated with the number of Y chromosomes. This suggests that sex-specific chromatin differences may contribute to sex-specific ageing in flies.</p>

Indicate the full web address (DOI or URL) giving public access to these data (if you have any problems with the deposit of your data, please contact contact@evolbiol.peercommunityin.org). In case all raw data are included in the preprint, indicate the DOI or URL of the preprint. *

https://www.biorxiv.org/content/10.1101/156042v2.supplementary-materialYou should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@evolbiol.peercommunityin.org). In case all raw scripts are included in the preprint, indicate the DOI or URL of the preprint. *

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Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@evolbiol.peercommunityin.org). In case all raw codes are included in the preprint, indicate the DOI or URL of the preprint. *

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Keywords (optional)

Sex gap in longevity, Toxic Y effect, Transposable elements, Chromatin

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Bioinformatics & Computational Biology, Expression Studies, Genetic conflicts, Genome Evolution, Genotype-Phenotype, Molecular Evolution, Reproduction and Sex

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Submission date

2020-07-28 15:06:18

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Gabriel Marais

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