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Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populationsuse asterix (*) to get italics
Michael Raatz, Arne Traulsen
<p style="text-align: justify;">When cancers or bacterial infections establish, small populations of cells have to free themselves from homoeostatic regulations that prevent their expansion. Trait evolution allows these populations to evade this regulation, escape stochastic extinction and climb up the fitness landscape. In this study, we analyse this complex process and investigate the fate of a cell population that underlies the basic processes of birth, death and mutation. We find that the shape of the fitness landscape dictates a circular adaptation trajectory in the trait space spanned by birth and death rates. We show that successful adaptation is less likely for parental populations with higher turnover (higher birth and death rates). Including density- or trait-affecting treatment we find that these treatment types change the adaptation dynamics in agreement with a geometrical analysis of fitness gradients. Treatment strategies that simultaneously target birth and death rates are most effective, but also increase evolvability. By mapping physiological adaptation pathways and molecular drug mechanisms to traits and treatments with clear eco-evolutionary consequences, we can achieve a much better understanding of the adaptation dynamics and the eco-evolutionary mechanisms at play in the dynamics of cancer and bacterial infections.</p> should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://
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Evolutionary rescue, Resistance evolution, Dormancy, Competitive release, Immune evasion
Evolutionary Dynamics, Evolutionary Ecology, Evolutionary Theory
Michael Doebeli, Jacob Scott, David Basanta, Anne-Florence Bitbol, Rob Noble, Ville Mustonen, Kateřina Staňková No need for them to be recommenders of PCIEvolBiol. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
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2022-06-18 08:44:37
Dominik Wodarz